WebJan 14, 2024 · An unsolved therapeutic problem in fibrosis is the overproduction of collagen. In order to screen the effect of anti-fibrotic drugs on collagen deposition, the Scar-in-a-Jar approach has been introduced about a decade ago. With macromolecular crowding a rapid deposition of collagen is seen, resulting in a substantial decrease in culture time, but the … WebHere we describe the Scar-in-a-Jar assay, an in vitro fibrosis model for anti-fibrotic drug testing that benefits from a substantially accelerated extracellular matrix deposition employing macromolecular crowding and a collagen-producing cell type of choice (e.g., …
A quantitative approach to scar analysis. Semantic Scholar
WebA quantitative approach to scar analysis. @article{Khorasani2011AQA, title={A quantitative approach to scar analysis.}, author={Hooman Khorasani and Zhong Zheng and Calvin Nguyen and Janette N. Zara and Xinli Zhang and Joyce Z. Wang and Kang Ting and Chia Soo}, journal={The American journal of pathology}, year={2011}, volume={178 2}, pages={ … WebBackground: Nucleic acid-based vaccines have been studied for the past four decades, but the approval of the first messenger RNA (mRNA) vaccines during the COVID-19 pandemic … money gold silver
Frontiers Macromolecular Crowding as a Tool to Screen Anti …
WebHere we describe the Scar-in-a-Jar assay, an in vitro fibrosis model for anti-fibrotic drug testing that benefits from a substantially accelerated extracellular matrix deposition … WebFeb 21, 2024 · Stage 2: Bulk cell populations with >90% indels were used to perform the Scar-in-a-Jar phenotypic assay. This assay measures type I collagen deposition and the … WebFeb 19, 2024 · The scar-in-a-jar assays are possible to perform in high-throughput format but have difficulty detecting effects of some drugs when the readout is based on ECM … icd 10 bloating and pain