Myh6-mercremer
WebMYH6-Cre becomes active at around embryonic day 8 [ 20 ], thereby causing the recombination of Ulk genes perinatally. cU1-KO mice were born with the same Mendelian frequency as wild-type littermates (Table S1) suggesting normal embryonic and perinatal development. cU2-KO mice, however, were born at slightly lower rates than wild-type … Web1 jul. 2024 · Genetic fate mapping was performed using an inducible, cardiomyocyte specific Myh6-MerCreMer mouse model, crossed with a LacZ reporter. A single large dose of …
Myh6-mercremer
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Web27 apr. 2024 · The alpha-MHC-MerCreMer (αMHC-MerCreMer) transgene has the mouse cardiac-specific alpha-myosin heavy chain promoter (αMHC or alpha-MHC; Myh6) … Web23 okt. 2024 · To achieve cardiomyocyte conditional deletion of AKAP2, 12-week-old double-transgenic Myh6-MerCreMer+/+AKAP2fl/flmice or Myh6-MerCreMer+/+control mice were injected intra-peritoneally for five consecutive days with 20 mg/kg of tamoxifen (Sigma-Aldrich, St. Louis, MO, USA).
Web1 jul. 2024 · Genetic fate mapping was performed using an inducible, cardiomyocyte specific Myh6-MerCreMer mouse model, crossed with a LacZ reporter. A single large dose of tamoxifen successfully labelled 70–80% of cardiomyocytes when administered at P0, and was followed by apical resection at P2. Web8 jun. 2024 · We generated Myh6-MerCreMer;Confetti +/− (MCM;Confetti) mice in which a single dose of tamoxifen leads to stochastic, indelible labeling of cardiomyocytes with 1 of 4 fluorescent proteins (Figure [A]). 4 By pulsing tamoxifen at postnatal day (P) 0 to P1, before significant binucleation or polyploidization occurs, 1,2 we ensured that labeled …
Web22 dec. 2024 · Myh6-MerCreMer Tg/0 mice were crossbred with Cul7 flox/flox mice to obtain Cul7 flox/flox Myh6-MerCreMer Tg/0 and Cul7 +/+ Myh6-MerCreMer Tg/0 control … Web23 jul. 2015 · Myh6MerCreMer/+ is a knock-in/knock-out allele for Myh6 and those mice developed normally without any evident defects in appearance or behavior in Black …
Web18 dec. 2024 · The Myh6-merCremer transgene model employed here is widely used in cardiac regeneration studies to assess the effects of altering the expression of loxP …
Web17 mrt. 2024 · In fact, Zhang et al. exploited this aspect of cardiomyocyte response to injury in their experimental strategy to identify “dedifferentiating” cardiomyocytes, noting that … delta healthcare providers worklogWebMyh6-Mcm: Myosin heavy chain 6-MerCreMer; F/M: female/male; HR: heart rate; bpm: beats per minute; AWT: anterior wall thickness; LVPWT: left ventricular posterior wall thickness; LVEDD: left ventricular end diastolic diameter; LVEDDi: LVEDD indexed to body weight; LVESD: left ventricular end systolic diameter; LVFS: left ventricular fractional … feuc trackingWeb15 dec. 2012 · Neither the heterozygous Myh6-MerCreMer/LepR flox/WT nor the Myh6-MerCreMer mice exhibited any overt signs of heart failure as observed in the homozygous LepR KO mice. Heart weight-to-body weight ratio was significantly elevated in Lepr KO compared with control mice and averaged 7.4 ± 0.4 vs. 5.6 ± 0.2 mg/g. feu college of law tuitionWeb005650 STOCK A1cf Tg(Myh6-cre/Esr1*)1Jmk /J The alpha-MHC-MerCreMer (αMHC-MerCreMer) transgene has the mouse cardiac-specific alpha-myosin heavy chain … feudal era of japanWebMoreover, the number of PH3 + cardiomyocytes was significantly higher in Myh6 mercremer:R26R-miR302-367 Tg/+ hearts than in Myh6 mercremer controls 3 weeks … delta healthcare providers slp salaryWeb13 sep. 2024 · Here, we generated a new Myh6-MerCreMer (Myh6(MerCreMer/+)) inducible Cre knock-in mouse by inserting a MerCreMer cassette into the Myh6 start codon. delta healthcare staff gardenWeb14 feb. 2024 · ECG strips from a wild type (Casq2+/+ Myh6-MERCreMER) and a mutant control (Casq2−/− Myh6-MERCreMER) mouse are shown in Figure 3A and B, … delta health care insurance