WebJun 20, 2024 · Network motifs defined as small graphlets that occur more frequently than expected by chance have revolutionized our understanding of feed-back circuits in cellular networks. However, with their definition solely based on statistical over-representation, network motifs often lack biological context, which limits their usefulness. WebOct 3, 2016 · Introduction. Networks are everywhere [].They are used to represent complex data associations from different domains ranging from social interactions and technological developments up to biological systems [].In biological sciences, network representations are predominantly adopted to depict metabolic pathways [], cell signaling cascades [4, 5], …
Biological network comparison using graphlet degree distribution
WebJan 28, 2024 · Typed graphlets are a powerful generalization of the notion of graphlet (network motif) to heterogeneous networks as they capture both the induced subgraph of interest and the types associated with the nodes in the induced subgraph. To address this problem, we propose a fast, parallel, and space-efficient framework for counting typed … WebDec 9, 2013 · Network graphlets and motifs are statistically highly recurrent patterns in graphs and networks that have been found to characterize families of networks and … how did chucky have a kid
A combinatorial approach to graphlet counting - OUP Academic
Graphlet degree vectors (signatures) and signature similarities were applied to biological networks to identify groups (or clusters) of topologically similar nodes in a network and predict biological properties of yet uncharacterized nodes based on known biological properties of characterized nodes. See more Graphlets in mathematics are induced subgraph isomorphism classes in a graph, i.e. two graphlet occurrences are isomorphic, whereas two graphlets are non-isomorphic. Graphlets differ from network motifs in … See more RGF-distance and GDD-agreement were used to evaluate the fit of various network models to real-world networks and to discover a new, well-fitting, geometric random graph model for protein-protein interaction networks, as well as other types of See more Relative graphlet frequency distance RGF-distance compares the frequencies of the appearance of all 3-5-node graphlets in two networks. Let Ni(G) be the number of graphlets of type $${\displaystyle i}$$ ($${\displaystyle i\in \{1,\ldots ,29\}}$$) … See more • [1] See more WebFrom social science to biology, numerous applications often rely on motifs for intuitive and meaningful characterization of networks at both the global macro-level as well as the local micro-level. WebLaurentino Quiroga Moreno, in Encyclopedia of Bioinformatics and Computational Biology, 2024. Network Motifs. Network motifs have been introduced by the group of Uri Alon … how many seasons in handmaid\u0027s tale