WebA Head-to-Head Comparison of Eneamide and Epoxyamide Inhibitors of Glucosamine-6-Phosphate Synthase from the Dapdiamide Biosynthetic Pathway The dapdiamides make up a family of antibiotics that have been presumed to be cleaved in the target cell to enzyme-inhibitory N-acyl-2,3-diaminopropionate (DAP) warheads containing two … WebJul 22, 2024 · Dapdiamide A synthase adds valine to the carboxylate of fumaramoyl …
Transcriptome Analysis of Durusdinium Associated with the
WebThe dapdiamides were discovered by constructing a genomic DNA library from Pantoea … WebApr 8, 2014 · OBJECTIVE: To inform neurologists about two ongoing trials of 3,4-DAP. … list of persons in the bible
KEGG ENZYME: 6.3.2.47 - Genome
WebThe enzyme, characterized from the bacterium Pantoea agglomerans, is involved in … WebJul 22, 2024 · In addition, a phylogenetic analysis of dapdiamide A (antibiotics) … WebHere we provide a rationale for this logic. We report that the R,R-epoxyamide warhead is a more efficient covalent inactivator of glucosamine-6-phosphate synthase by 1 order of magnitude versus the eneamide, and this difference correlates with a >10-fold difference in antibiotic activity for the corresponding acyl-DAP dipeptides. imf/world bank annual meetings april 2023