WebThis new understanding of the determinants of nuclear retention and cytoplasmic export provides a deeper understanding of how … WebJul 11, 2024 · The rapid accumulation of TFEB in the cytoplasm would be consistent with its active nuclear export. Similar results were observed following addition and subsequent removal of the MEK inhibitor...
Nuclear export signal - Wikipedia
WebJan 5, 2024 · Nuclear Export Signals Nucleotides, Cyclic Receptors, Cytoplasmic and Nuclear STING1 protein, human cyclic guanosine monophosphate-adenosine monophosphate exportin 1 protein Interferon-beta DNA Nucleotidyltransferases cGAS protein, human leptomycin B Grant support CCI-132561 /CIHR/Canada WebSep 2, 2005 · Like the Balbiani ring mRNAs, many mRNAs enter the translationally active pool immediately upon export to the cytoplasm. At this stage, the 5′ cap is still largely bound by the nuclear CBC20/80 complex, whereas the poly(A) tail carries a mixture of nuclear and cytoplasmic poly(A) binding proteins PABPN1 and PABPCs ( Table 1 ). fnf vs core
Sequence Determinants for Nuclear Retention and Cytoplasmic Export of ...
WebSep 17, 2008 · The cytoplasmic translation factor eEF1A has been implicated in the nuclear export of tRNA species in lower eukaryotes. Here we demonstrate that eEF1A plays a central role in nuclear export of proteins in mammalian cells. TD-NEM (transcription-dependent nuclear export motif), a newly characterized nuclear export signal, mediates … WebThe export of many types of RNA from the nucleus is required for proper cellular function. The NES determines what type of pathway the varying types of RNA may use to exit the … WebMay 22, 2024 · In order to allow the exchange of proteins between the nucleus and cytoplasm, proteins must be transported efficiently through the nuclear pore complex … greenville upmc horizon hospital