Cisplatin transplatin
WebCisplatin is a platinum-based agent whose nephrotoxicity is thought related to the chloride in the cis position. Cisplatin gains entry into tubular cells via uptake by the OCT-2 … WebMost recent answer. 21st Dec, 2024. Shivendra Vikram Singh. St. Jude Children's Research Hospital. Cisplatin 2 mg/ml dissolved in 0.9% saline. Cite.
Cisplatin transplatin
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WebCisplatin is the father of a number of other second and subsequent generation platinum anti-cancer drugs of which carboplatin and oxaliplatin with their more stable bidentate ligands and fewer side effects are perhaps the best known. These refined compounds are less harmful to the kidneys but are also less potent. Cisplatin interferes with DNA replication, which kills the fastest proliferating cells, which in theory are cancerous. Following administration, one chloride ion is slowly displaced by water to give the aquo complex cis-[PtCl(NH3)2(H2O)] , in a process termed aquation. Dissociation of the chloride is favored inside the cell because the intracellular chloride concentration is only 3–20% of the approxi…
WebDec 19, 2024 · Different Effects of Cisplatin and Transplatin on the Higher-Order Structure of DNA and Gene Expression. ... R.G. GAP161 targets and downregulates G3BP to suppress cell growth and potentiate cisplatin-mediated cytotoxicity to colon carcinoma HCT116 cells. Cancer Sci. 2012, 103, 1848–1856. [Google Scholar] Dou, N.; Chen, J.D.; … WebCisplatin and transplatin were purchased from Sigma Chemical Co. (St. Louis, MO). Solutions containing cisand trans-diammineaquachloroplatinum (ID ion were prepared from a hydrolysis equilibrium obtained by dissolving cis- and transplatin in distilled water (1 mM).
WebThe interaction of cis-DDP and trans-DDP (DDP = [PtCl2(NH3)(2)]) with the C-terminal zinc finger (ZF2) of the HIVNCp7 nucleocapsid protein was investigated by fluorescence, circular dichroism, mass s WebJan 29, 2024 · Compositions and methods for the treatment of cancer are provided. Specifically, the disclosure provides a method for treating and/or inhibiting cancer or neoplasia in a subject, the method comprises contacting cancer cells obtained from the subject to be treated with an inhibitor of an immunity suppressing tumor protein; …
WebSep 28, 2024 · Cisplatin binds to DNA and other cellular components and triggers apoptosis, whereas transplatin is clinically ineffective. Here, a 244 nm UVRR study shows that purine UVRR bands are altered in frequency and intensity when mononucleotides are treated with cisplatin.
WebMolecular structure, IR spectra, and chemical reactivity of cisplatin and transplatin DFT studies, basis set effect and solvent effect.pdf. 2015-10-16 ... bingo countersWebCisplatin and transplatin.svg. From Wikimedia Commons, the free media repository. File. File history. File usage on Commons. File usage on other wikis. Metadata. Size of this … d2s innovationWebNephrotoxicity is the dose-limiting toxic effect of cis-dichlorodiammineplatinum (cis-platin) in humans. Its stereoisomer transplatin does not have any toxicity at equimolar concentrations, and it also possesses little antitumor activity. In this study, subcellular localization of both the platinum isomers was examined in the liver and kidney ... bingo counter onlineWebJan 17, 2024 · Cisplatin is classically known to exhibit anticancer activity through DNA damage in the nucleus. Here we found a mechanism by which cisplatin affects iron metabolism, leading to toxicity and cell death. Cisplatin causes intracellular iron deficiency through direct inhibition of the master regulator … bingo couchWebcis-platin Dichloroplatine, diammoniate [French] [ACD/IUPAC Name] Dichloroplatinum diammoniate [ACD/IUPAC Name] Dichlorplatindiammoniat [German] [ACD/IUPAC … d2 silver cheapWebCisplatin, cis-PtCl2(NH3)2, is a leading antitumor drug of impressive efficacy, used both alone and in combination with other drugs for the treatment of various kinds of solid tumors.1–5 The anticancer activity of … bingo country boys downloadWebDec 19, 2024 · To investigate the effects of cisplatin and transplatin on the higher-order structure of DNA, we used FM to observe single DNA molecules in the presence or absence of cisplatin or transplatin. … bingo counters and bag