WebNov 19, 2024 · Increased circANKS1B expression was closely associated with lymph node metastasis and advanced clinical stage and served as an independent risk factor for overall survival of breast cancer patients. Functional studies revealed that circANKS1B promoted breast cancer invasion and metastasis both in vitro and in vivo by inducing epithelial-to ... WebNov 28, 2024 · circANKS1B, arising from exons 5 to 8 of the ANKS1B gene, is markedly overexpressed in TNBC compared to normal tissues and other subtypes of BC . Functional experiments have shown that circANKS1B promotes the epithelial-mesenchymal transition (EMT) to facilitate BC invasion and metastasis both in vitro and in vivo, but has no effect …
circANKS1B regulates FOXM1 expression and promotes …
WebMay 10, 2024 · CircANKS1B used miR-148a-3p and miR-152-3p to intensify the expression of the transcription factor USF1, consequently activating the TGF-β1/Smad regulatory circuit to increase EMT. Studies declared that circNR3C2 [ 107 ], hsa_circ_0006220, circTADA2A-E6 and circITCH had a negative impression on the regulation of metastasis through … WebDec 3, 2024 · Consequently, circANKS1B induces EMT by sponging miR-148a-3p and miR-152-3p. 83 Moreover, upregulated circANKS1B expression, which promotes migration and invasion of cancer cells, served as an independent risk factor for poor OS in patients with BC. 83 Other circRNAs, such as circAGFG1, circKIF4A, and circPLK1, are also … dalis delaware county ohio
Circular RNAs: implications of signaling pathways and …
Webcancer patients [18]. Furthermore, circANKS1B also acts as a sponge of miR-149 to promote colorectal cancer cell migration and invasion [19]. Analogously, circANKS1B … WebFurthermore, circANKS1B also acts as a sponge of miR-149 to promote colorectal cancer cell migration and invasion . Analogously, circANKS1B can sponge miR-148-3p and … WebMay 11, 2024 · The results suggest that circANKS1B is an interesting circRNAs to study in order to find alternative therapeutic strategies for inhibiting breast cancer metastasis. CircRNAs in lung cancer Lung cancer is one of the most common cancers in the world with 5-year survival rates varying from 92 to 0%, depending on disease stage at diagnosis 58 . bip install